{"id":446,"date":"2026-07-09T18:24:12","date_gmt":"2026-07-09T09:24:12","guid":{"rendered":"https:\/\/komta.or.kr\/?p=446"},"modified":"2026-07-09T18:24:12","modified_gmt":"2026-07-09T09:24:12","slug":"km-research-technical-report-2026-01","status":"publish","type":"post","link":"https:\/\/komta.or.kr\/?p=446","title":{"rendered":"KM Research Technical Report 2026-01"},"content":{"rendered":"\n

\ubcd1\ud480 \uc720\ub798 \uc138\ud3ec\uc678\uc18c\ud3ec CICA-EV\uc758 \ud53c\ubd80 \uac1c\uc120 \ubb3c\uc9c8 \uac00\ub2a5\uc131 \ubd84\uc11d<\/h1>\n\n\n\n

\ucf5c\ub77c\uac90 \ub300\uc0ac, \ubaa8\uacf5 \uc9c0\ud45c, \uc8fc\ub984 \uae4a\uc774, \ud53c\ubd80 \uc218\ubd84 \ubc0f \ud53c\ubd80 \ubc00\ub3c4 \uac1c\uc120 \uac00\ub2a5\uc131\uc744 \uc911\uc2ec\uc73c\ub85c<\/h2>\n\n\n\n

\ubc1c\ud589\uae30\uad00
KM\ub9ac\uc11c\uce58<\/p>\n\n\n\n

\ubd84\uc11d \ub300\uc0c1
Centella asiatica-derived extracellular vesicles, CICA-EV<\/p>\n\n\n\n

\uc8fc\uc694 \ubd84\uc11d \ubb38\ud5cc
Hannah S. Park and Sehyun Shin, \u201cClinical Efficacy and Safety Evaluation of a Centella asiatica (CICA)-Derived Extracellular Vesicle Formulation for Anti-Aging Skincare,\u201d Cosmetics, 2025, 12(4), 135.<\/p>\n\n\n\n

\ubc1c\ud589\uc77c
2026\ub144 7\uc6d4 09\uc77c<\/p>\n\n\n\n

\n\n\n\n

\ucd08\ub85d<\/h2>\n\n\n\n

\ubcf8 \ub9ac\ud3ec\ud2b8\ub294 \ubcd1\ud480 \uc720\ub798 \uc138\ud3ec\uc678\uc18c\ud3ec\uc778 CICA-EV\uc758 \ud53c\ubd80 \uac1c\uc120 \ubb3c\uc9c8 \uac00\ub2a5\uc131\uc744 \ubd84\uc11d\ud558\uae30 \uc704\ud574 \uc791\uc131\ub410\ub2e4. \ubd84\uc11d\uc758 \uc911\uc2ec \ubb38\ud5cc\uc740 MDPI Cosmetics\uc5d0 \uac8c\uc7ac\ub41c \u201cClinical Efficacy and Safety Evaluation of a Centella asiatica (CICA)-Derived Extracellular Vesicle Formulation for Anti-Aging Skincare\u201d\uc774\ub2e4. \ud574\ub2f9 \ub17c\ubb38\uc740 CICA \uc720\ub798 extracellular vesicles\uac00 \ud3ec\ud568\ub41c \uad6d\uc18c \ub3c4\ud3ec \uc570\ud50c \uc81c\ud615\uc758 \uc548\uc804\uc131\uacfc \ud53c\ubd80 \uac1c\uc120 \uc9c0\ud45c\ub97c \uac74\uac15\ud55c \ud55c\uad6d \uc131\uc778\uc744 \ub300\uc0c1\uc73c\ub85c \ud3c9\uac00\ud588\ub2e4. \ub17c\ubb38\uc740 2025\ub144 6\uc6d4 25\uc77c \uac8c\uc7ac\ub410\uc73c\uba70, DOI\ub294 10.3390\/cosmetics12040135\ub2e4.<\/p>\n\n\n\n

CICA-EV\ub294 \uae30\uc874 \ubcd1\ud480\u00b7\uc2dc\uce74 \uc6d0\ub8cc\uac00 \uc8fc\ub85c \ud53c\ubd80 \uc9c4\uc815\uacfc \uc7a5\ubcbd \uad00\ub9ac \uc601\uc5ed\uc5d0\uc11c \ud65c\uc6a9\ub3fc \uc628 \uac83\uacfc \ub2ec\ub9ac, \ucf5c\ub77c\uac90 \uc0dd\uc131, \ucf5c\ub77c\uac90 \ubd84\ud574 \ud6a8\uc18c \uc5b5\uc81c, \ubaa8\uacf5 \uc678\uad00, \uc8fc\ub984 \uae4a\uc774, \ud53c\ubd80 \uc218\ubd84, \ud53c\ubd80 \ubc00\ub3c4, \ud53c\ubd80 \uc790\uadf9\uc131 \uc9c0\ud45c\ub97c \ud568\uaed8 \uc81c\uc2dc\ud588\ub2e4\ub294 \uc810\uc5d0\uc11c \uc8fc\ubaa9\ub41c\ub2e4. \ub17c\ubb38\uc5d0 \ub530\ub974\uba74 CICA-EV \ud568\uc720 \uc81c\ud615\uc740 24\uc2dc\uac04 \ud328\uce58 \ud14c\uc2a4\ud2b8\uc5d0\uc11c \uc790\uadf9 \uc9c0\uc218 0.00\uc744 \ubcf4\uc600\uace0, 2\uc8fc \uc801\uc6a9\uc2dc\ud5d8\uc5d0\uc11c \ud3c9\uade0 \ubaa8\uacf5 \uba74\uc801 17.9% \uac10\uc18c, \ubaa8\uacf5 \ubc00\ub3c4 26.9% \uac10\uc18c, \ud53c\ubd80 \ud45c\uba74 \uac70\uce60\uae30 9.0% \uac10\uc18c, \uc8fc\ub984 \uae4a\uc774 7.8~18.8% \uac10\uc18c, 0.5mm \uae4a\uc774 \ud53c\ubd80 \uc218\ubd84 7.9% \uc99d\uac00, \ud53c\ubd80 \ubc00\ub3c4 12.7% \uac1c\uc120\uc744 \ub098\ud0c0\ub0c8\ub2e4.<\/p>\n\n\n\n

KM\ub9ac\uc11c\uce58\ub294 CICA-EV\ub97c \ub2e8\uc21c \uc2dd\ubb3c \ucd94\ucd9c\ubb3c\uc758 \uc5f0\uc7a5\uc120\uc774 \uc544\ub2c8\ub77c, \ubcd1\ud480 \uc720\ub798 \uc6d0\ub8cc\ub97c \uc138\ud3ec\uc678\uc18c\ud3ec \uae30\uc220\ub85c \uace0\ub3c4\ud654\ud55c \ubc14\uc774\uc624 \uae30\ubc18 \ud53c\ubd80 \uac1c\uc120 \ud6c4\ubcf4 \ubb3c\uc9c8\ub85c \ud3c9\uac00\ud55c\ub2e4. \ud2b9\ud788 \ucf5c\ub77c\uac90 \ub300\uc0ac \uc870\uc808 \uac00\ub2a5\uc131\uacfc \ud53c\ubd80 \ud45c\uba74 \uc9c0\ud45c \uac1c\uc120, \uc218\ubd84\u00b7\ubc00\ub3c4 \ubcf4\uac15 \uc9c0\ud45c\uac00 \ub3d9\uc2dc\uc5d0 \uc81c\uc2dc\ub410\ub2e4\ub294 \uc810\uc740 CICA-EV\uc758 \ud559\uc220\uc801\u00b7\uc18c\uc7ac\uc801 \uc758\ubbf8\ub97c \uc124\uba85\ud558\ub294 \ud575\uc2ec \uadfc\uac70\ub2e4.<\/p>\n\n\n\n

\n\n\n\n

1. \ubd84\uc11d \ubc30\uacbd<\/h2>\n\n\n\n

\ud53c\ubd80 \uac1c\uc120 \uc18c\uc7ac\uc758 \ud3c9\uac00\ub294 \ub2e8\uc77c \ud6a8\ub2a5 \uc8fc\uc7a5\ubcf4\ub2e4 \ub2e4\uce35\uc801 \uc9c0\ud45c\uc758 \uc77c\uad00\uc131\uc744 \ud544\uc694\ub85c \ud55c\ub2e4. \ud53c\ubd80 \ub178\ud654\uc640 \ud53c\ubd80 \uc678\uad00 \ubcc0\ud654\ub294 \ucf5c\ub77c\uac90 \uac10\uc18c, \uc138\ud3ec\uc678\uae30\uc9c8 \ubd84\ud574, \uc218\ubd84 \uc800\ud558, \ud45c\uba74 \uac70\uce60\uae30 \uc99d\uac00, \ubaa8\uacf5 \uc678\uad00 \ubcc0\ud654, \uc8fc\ub984 \uae4a\uc774 \uc99d\uac00 \ub4f1\uc774 \ubcf5\ud569\uc801\uc73c\ub85c \uc791\uc6a9\ud558\ub294 \uacfc\uc815\uc774\ub2e4.<\/p>\n\n\n\n

\ubcd1\ud480\uc740 \uc624\ub79c \uae30\uac04 \ud53c\ubd80 \uc9c4\uc815, \uc190\uc0c1 \ud53c\ubd80 \uad00\ub9ac, \uc7a5\ubcbd \ucf00\uc5b4 \uc131\ubd84\uc73c\ub85c \ud65c\uc6a9\ub3fc \uc654\ub2e4. \uadf8\ub7ec\ub098 \ubcd1\ud480 \uc720\ub798 \uc138\ud3ec\uc678\uc18c\ud3ec\uc778 CICA-EV\ub294 \uc77c\ubc18 \ubcd1\ud480 \ucd94\ucd9c\ubb3c\uacfc \uad6c\ubd84\ub418\ub294 \uc18c\uc7ac\uc801 \ud2b9\uc131\uc744 \uac16\ub294\ub2e4. \uc138\ud3ec\uc678\uc18c\ud3ec\ub294 \uc9c0\uc9c8 \uc774\uc911\ub9c9 \uad6c\uc870\ub97c \uac00\uc9c4 \ub098\ub178 \ud06c\uae30 \uc785\uc790\ub85c, \ub2e8\ubc31\uc9c8\u00b7\uc9c0\uc9c8\u00b7\ud575\uc0b0 \ub4f1 \uc0dd\uccb4 \uc2e0\ud638 \uad00\ub828 \ubb3c\uc9c8\uc744 \ud3ec\ud568\ud560 \uc218 \uc788\ub294 \uc804\ub2ec\uccb4\ub85c \uc5f0\uad6c\ub418\uace0 \uc788\ub2e4. \ud574\ub2f9 \ub17c\ubb38\ub3c4 \uc2dd\ubb3c \uc720\ub798 EV\ub97c \ucc28\uc138\ub300 \uc0dd\ub9ac\ud65c\uc131 \uc18c\uc7ac\uad70\uc73c\ub85c \uc124\uba85\ud558\uace0, CICA \uc720\ub798 EV\ub97c \uace0\ub3c4\ud654\ub41c \ud56d\ub178\ud654 \uc2a4\ud0a8\ucf00\uc5b4 \uc18c\uc7ac\ub85c \ud3c9\uac00\ud588\ub2e4.<\/p>\n\n\n\n

\ubcf8 \ub9ac\ud3ec\ud2b8\uc758 \ubaa9\uc801\uc740 CICA-EV\ub97c \uc81c\ud488 \ud64d\ubcf4 \uad00\uc810\uc774 \uc544\ub2c8\ub77c \ud53c\ubd80 \uac1c\uc120 \ubb3c\uc9c8 \uad00\uc810\uc5d0\uc11c \uac80\ud1a0\ud558\ub294 \ub370 \uc788\ub2e4. \uc774\uc5d0 \ub530\ub77c \ubd84\uc11d\uc758 \ucd08\uc810\uc740 \ub124 \uac00\uc9c0\ub2e4.<\/p>\n\n\n\n

\uccab\uc9f8, CICA-EV\uc758 \ubd84\ub9ac\u00b7\uc815\uc81c \ubc0f \ubb3c\ub9ac\uc801 \ud2b9\uc131\uc774\ub2e4.
\ub458\uc9f8, \ucf5c\ub77c\uac90 \uc0dd\uc131\uacfc \ubd84\ud574 \uc5b5\uc81c \uad00\ub828 \uc0dd\ubb3c\ud559\uc801 \uc9c0\ud45c\ub2e4.
\uc14b\uc9f8, \uc778\uccb4 \uc801\uc6a9\uc2dc\ud5d8\uc5d0\uc11c \ud655\uc778\ub41c \ubaa8\uacf5\u00b7\uc8fc\ub984\u00b7\uc218\ubd84\u00b7\ud53c\ubd80 \ubc00\ub3c4 \uc9c0\ud45c\ub2e4.
\ub137\uc9f8, \uad6d\uc18c \ub3c4\ud3ec \uc81c\ud615\uc73c\ub85c\uc11c\uc758 \ud53c\ubd80 \uc801\ud569\uc131\uacfc \ud574\uc11d \ud55c\uacc4\ub2e4.<\/p>\n\n\n\n

\n\n\n\n

2. \ubd84\uc11d \ub300\uc0c1 \ubb3c\uc9c8<\/h2>\n\n\n\n

2.1 CICA-EV\uc758 \uc815\uc758<\/h2>\n\n\n\n

CICA-EV\ub294 Centella asiatica, \uc989 \ubcd1\ud480\uc5d0\uc11c \uc720\ub798\ud55c extracellular vesicles\ub97c \uc758\ubbf8\ud55c\ub2e4. \ub17c\ubb38\uc5d0\uc11c\ub294 CICA \uc720\ub798 EV\ub97c \ud3ec\ud568\ud55c \uad6d\uc18c \ub3c4\ud3ec \uc570\ud50c \uc81c\ud615\uc744 \ub300\uc0c1\uc73c\ub85c \uc548\uc804\uc131\uacfc \uc720\ud6a8\uc131\uc744 \ud3c9\uac00\ud588\ub2e4. \ud574\ub2f9 \uc81c\ud615\uc740 CICA Exosome Ampoule, ExoGlow\ub85c \uba85\uc2dc\ub410\uc73c\uba70, JUVEV\u00ae, Microgentas, Seoul, Republic of Korea\uac00 \uc81c\ud488 \uc815\ubcf4\ub85c \uae30\uc7ac\ub410\ub2e4.<\/p>\n\n\n\n

\ubcf8 \ub9ac\ud3ec\ud2b8\uc5d0\uc11c CICA-EV\ub294 \ud2b9\uc815 \uc18c\ube44\uc7ac \ube0c\ub79c\ub4dc\uac00 \uc544\ub2c8\ub77c \ud53c\ubd80 \uac1c\uc120 \ud6c4\ubcf4 \ubb3c\uc9c8\ub85c \ub2e4\ub8ec\ub2e4. \uc81c\ud488\uba85\uc740 \ub17c\ubb38\uc5d0\uc11c \uc0ac\uc6a9\ub41c \uc2dc\ud5d8 \uc81c\ud615\uc744 \uc2dd\ubcc4\ud558\uae30 \uc704\ud55c \uc815\ubcf4\ub85c\ub9cc \uc0ac\uc6a9\ud55c\ub2e4.<\/p>\n\n\n\n

2.2 \ubd84\ub9ac\u00b7\uc815\uc81c \ud2b9\uc131<\/h2>\n\n\n\n

\ub17c\ubb38\uc5d0 \ub530\ub974\uba74 CICA \uc720\ub798 \ucd94\ucd9c\ubb3c\uc740 \ub9c8\uc774\ud06c\ub85c\uc820\ud0c0\uc2a4\uc758 ExoFilter \ud50c\ub7ab\ud3fc\uc744 \uc774\uc6a9\ud574 \ucc98\ub9ac\ub410\ub2e4. ExoFilter\ub294 \uc804\uae30\ub3d9\ub825 \ubcf4\uc870 \uba54\uc26c \uc5ec\uacfc \uc2dc\uc2a4\ud15c\uc73c\ub85c \uc124\uba85\ub418\uba70, \uc591\uc804\ud558 \ucc98\ub9ac\ub41c \ub2e4\uce35 \uba54\uc26c\uac00 \uc74c\uc804\ud558\ub97c \ub760\ub294 \uc138\ud3ec\uc678\uc18c\ud3ec\ub97c \uc120\ud0dd\uc801\uc73c\ub85c \uacb0\ud569\uc2dc\ud0a4\uace0 \ubd88\uc21c\ubb3c\uc744 \ud1b5\uacfc\uc2dc\ud0a4\ub294 \ubc29\uc2dd\uc73c\ub85c \uc81c\uc2dc\ub410\ub2e4.<\/p>\n\n\n\n

SEM \ubc0f TEM \uad00\ucc30\uc5d0\uc11c\ub294 CICA \uc720\ub798 \ub098\ub178\uc785\uc790\uac00 \uc57d 100~150nm \ud06c\uae30\uc758 \ucef5 \ud615\ud0dc \uc18c\ud3ec\uc640 \uc774\uc911\ub9c9 \uad6c\uc870\ub97c \ubcf4\uc778 \uac83\uc73c\ub85c \ubcf4\uace0\ub410\ub2e4. \ub098\ub178\uc785\uc790 \ucd94\uc801 \ubd84\uc11d\uc5d0\uc11c\ub294 \uc785\uc790 \ud06c\uae30 \ubd84\ud3ec\uc758 \ud53c\ud06c\uac00 \uc57d 130nm\ub85c \ud655\uc778\ub410\uace0, \ucd1d \ub18d\ub3c4\ub294 2.3 \u00d7 10\u2079 particles\/mL\ub85c \uc81c\uc2dc\ub410\ub2e4.<\/p>\n\n\n\n

\uc774 \ubb3c\ub9ac\uc801 \ud2b9\uc131\uc740 CICA-EV\uac00 \uc77c\ubc18 \uc2dd\ubb3c \ucd94\ucd9c\ubb3c\uacfc \uad6c\ubd84\ub418\ub294 \ub098\ub178 \uc18c\ud3ec\uccb4 \uae30\ubc18 \uc18c\uc7ac\uc784\uc744 \ubcf4\uc5ec\uc900\ub2e4. \ud2b9\ud788 \ud06c\uae30, \ud615\ud0dc, \ub18d\ub3c4, \uc774\uc911\ub9c9 \uad6c\uc870\uac00 \uc81c\uc2dc\ub410\ub2e4\ub294 \uc810\uc740 \uc18c\uc7ac \uc815\uccb4\uc131 \ud655\ubcf4 \uce21\uba74\uc5d0\uc11c \uc911\uc694\ud558\ub2e4.<\/p>\n\n\n\n

\n\n\n\n

3. \uc2dc\ud5d8 \uc81c\ud615 \ubc0f \uc5f0\uad6c \uc124\uacc4<\/h2>\n\n\n\n

3.1 \uc2dc\ud5d8 \uc81c\ud615<\/h2>\n\n\n\n

\ub17c\ubb38\uc740 CICA-EV \uc570\ud50c\uc744 \ud22c\uba85\ud55c \uc218\uc131 \uc138\ub7fc \uc81c\ud615\uc73c\ub85c \uc124\uba85\ud55c\ub2e4. \ud574\ub2f9 \uc81c\ud615\uc740 \uace0\uc21c\ub3c4 CICA \uc720\ub798 \uc5d1\uc18c\uc880 20,000ppm\uacfc \ubcf4\uc2b5 \ubc0f \uc7a5\ubcbd \uac15\ud654 \uc131\ubd84\uc744 \ud568\uaed8 \ud3ec\ud568\ud558\ub294 \uac83\uc73c\ub85c \uae30\uc7ac\ub410\ub2e4.<\/p>\n\n\n\n

\uc774 \uc810\uc740 \ud574\uc11d\uc0c1 \uc911\uc694\ud558\ub2e4. \uc778\uccb4 \uc801\uc6a9\uc2dc\ud5d8 \uacb0\uacfc\ub294 CICA-EV \ub2e8\uc77c \ubb3c\uc9c8\uc758 \uc808\ub300 \ud6a8\uacfc\uac00 \uc544\ub2c8\ub77c, CICA-EV\uac00 \ud3ec\ud568\ub41c \uad6d\uc18c \ub3c4\ud3ec \uc81c\ud615\uc758 \uc801\uc6a9 \uacb0\uacfc\ub85c \ubcf4\ub294 \uac83\uc774 \ud559\uc220\uc801\uc73c\ub85c \uc801\uc808\ud558\ub2e4. \ub2e4\ub9cc \ud574\ub2f9 \uc81c\ud615\uc758 \ud575\uc2ec \ud65c\uc131 \uc18c\uc7ac\uac00 CICA \uc720\ub798 EV\ub77c\ub294 \uc810\uc5d0\uc11c, CICA-EV\uc758 \ud53c\ubd80 \uac1c\uc120 \uac00\ub2a5\uc131\uc744 \ud3c9\uac00\ud558\ub294 \uadfc\uac70\ub85c \ud65c\uc6a9\ud560 \uc218 \uc788\ub2e4.<\/p>\n\n\n\n

3.2 \uc2dc\ud5d8 \ub300\uc0c1 \ubc0f \uc724\ub9ac \uae30\uc900<\/h2>\n\n\n\n

\uc5f0\uad6c\ub294 \ub450 \uac1c\uc758 \ub3c5\ub9bd \uc2dc\ud5d8\uc73c\ub85c \uad6c\uc131\ub410\ub2e4. \uccab \ubc88\uc9f8\ub294 30\uba85\uc758 \uac74\uac15\ud55c \uc131\uc778 \uc9c0\uc6d0\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c 24\uc2dc\uac04 \ud53c\ubd80 \uc790\uadf9 \ud3c9\uac00\uc600\uace0, \ub450 \ubc88\uc9f8\ub294 20\uba85\uc758 \uc131\uc778 \uc5ec\uc131 \ub300\uc0c1 2\uc8fc \ud6a8\ub2a5 \ud3c9\uac00\uc600\ub2e4. \ud6a8\ub2a5 \ud3c9\uac00\uad70\uc758 \ud3c9\uade0 \uc5f0\ub839\uc740 50.7\uc138\uc600\uc73c\uba70, \uc5f0\uad6c\ub294 ACE Clinical Research Center\uc5d0\uc11c \uc218\ud589\ub410\ub2e4. \uc5f0\uad6c\ub294 \ud5ec\uc2f1\ud0a4 \uc120\uc5b8, \uad6d\ub0b4 \uc0dd\uba85\uc724\ub9ac \ubc0f \uc548\uc804 \uad00\ub828 \ubc95\ub839, ICH-GCP, \uc2dd\ud488\uc758\uc57d\ud488\uc548\uc804\ucc98 \ud654\uc7a5\ud488 \uc778\uccb4\uc801\uc6a9\uc2dc\ud5d8 \uad00\ub828 \uae30\uc900\uc5d0 \ub530\ub77c \uc218\ud589\ub410\uace0, ACE Clinical Research Center IRB \uc2b9\uc778\uc744 \ubc1b\uc558\ub2e4.<\/p>\n\n\n\n

3.3 \uc801\uc6a9 \ubc29\uc2dd\uacfc \uce21\uc815 \ubc29\ubc95<\/h2>\n\n\n\n

\ud6a8\ub2a5 \ud3c9\uac00\uc5d0\uc11c \ucc38\uac00\uc790\ub294 CICA-EV \uc570\ud50c\uc744 14\uc77c \ub3d9\uc548 \ud558\ub8e8 \ub450 \ucc28\ub840, \uc544\uce68\uacfc \uc800\ub141\uc5d0 \uc5bc\uad74\uc5d0 \ub3c4\ud3ec\ud588\ub2e4. \uce21\uc815\uc740 \uae30\uc800 \uc2dc\uc810\uacfc \ucd5c\uc885 \uc801\uc6a9 \ud6c4 \uc9c4\ud589\ub410\ub2e4. \ubaa8\uacf5\uacfc \uc8fc\ub984\uc740 Antera 3D \uc2dc\uc2a4\ud15c\uc744 \uc774\uc6a9\ud574 \uce21\uc815\ub410\uace0, \ud53c\ubd80 \uc218\ubd84\uc740 MoistureMeter D\ub97c \ud1b5\ud574 0.5mm, 1.5mm, 2.5mm \uae4a\uc774\uc5d0\uc11c \ud3c9\uac00\ub410\ub2e4. \ud53c\ubd80 \ubc00\ub3c4\ub294 Ultrascan UC22 \uc7a5\ube44\ub97c \ud1b5\ud574 \uce21\uc815\ub410\ub2e4.<\/p>\n\n\n\n

\uc774 \uc5f0\uad6c \uc124\uacc4\ub294 \ud654\uc7a5\ud488 \uc778\uccb4 \uc801\uc6a9\uc2dc\ud5d8\uc73c\ub85c\uc11c \ud45c\uc900\ud654\ub41c \uc870\uac74\uc744 \uac16\ucdc4\ub2e4. \ub3d9\uc77c \uc138\uc548\uc81c \uc0ac\uc6a9, \uce21\uc815 \uc804 \uc548\uc815\ud654 \uc2dc\uac04, \uc628\uc2b5\ub3c4 \ud1b5\uc81c \ub4f1\uc740 \ud53c\ubd80 \uce21\uc815\uac12\uc758 \ubcc0\ub3d9\uc131\uc744 \uc904\uc774\uae30 \uc704\ud55c \uc7a5\uce58\ub85c \ud574\uc11d\ub41c\ub2e4.<\/p>\n\n\n\n

\n\n\n\n

4. \ud53c\ubd80 \uc790\uadf9\uc131 \ud3c9\uac00<\/h2>\n\n\n\n

CICA-EV \ud568\uc720 \uc81c\ud615\uc740 24\uc2dc\uac04 \ud3d0\uc1c4 \ucca9\ud3ec \ubc29\uc2dd\uc73c\ub85c \ud53c\ubd80 \uc790\uadf9 \uac00\ub2a5\uc131\uc774 \ud3c9\uac00\ub410\ub2e4. 30\uba85\uc758 \uac74\uac15\ud55c \uc131\uc778\uc744 \ub300\uc0c1\uc73c\ub85c \uc0c1\ubd80 \ub4f1 \ubd80\uc704\uc5d0 \uc2dc\ud5d8 \uc81c\ud615\uc744 \uc801\uc6a9\ud588\uace0, \ud53c\ubd80\uacfc \uc804\ubb38\uc758\uac00 \ud328\uce58 \uc81c\uac70 \ud6c4 30\ubd84 \ubc0f 24\uc2dc\uac04 \uc2dc\uc810\uc758 \ud53c\ubd80 \ubc18\uc751\uc744 \ud3c9\uac00\ud588\ub2e4.<\/p>\n\n\n\n

\uacb0\uacfc\uc801\uc73c\ub85c \ubaa8\ub4e0 \ub300\uc0c1\uc790\uc5d0\uc11c \ud64d\ubc18, \ubd80\uc885 \ub610\ub294 \uae30\ud0c0 \uc790\uadf9 \ubc18\uc751\uc774 \uad00\ucc30\ub418\uc9c0 \uc54a\uc558\uc73c\uba70, \ud3c9\uade0 \uc790\uadf9 \uc810\uc218\ub294 0.00\uc73c\ub85c \ubcf4\uace0\ub410\ub2e4. \ub17c\ubb38\uc740 \uc774\ub97c \u201cExcellent\u201d, \uc989 \ube44\uc790\uadf9\uc131\uc73c\ub85c \ubd84\ub958\ud588\ub2e4. \ub610\ud55c 2\uc8fc \ud6a8\ub2a5 \ud3c9\uac00 \uae30\uac04\uc5d0\ub3c4 \uac00\ub824\uc6c0, \uac74\uc870, \uc811\ucd09\uc131 \ud53c\ubd80\uc5fc \ub4f1\uc758 \uc774\uc0c1 \ud53c\ubd80 \ubc18\uc751\uc740 \ubcf4\uace0\ub418\uc9c0 \uc54a\uc558\ub2e4.<\/p>\n\n\n\n

\ud53c\ubd80 \uac1c\uc120 \ubb3c\uc9c8 \uad00\uc810\uc5d0\uc11c \uc774 \uacb0\uacfc\ub294 \uc911\uc694\ud558\ub2e4. \uace0\uae30\ub2a5\uc131 \uc18c\uc7ac\ub294 \ud65c\uc131 \uc9c0\ud45c\uc640 \ud568\uaed8 \ud53c\ubd80 \uc801\ud569\uc131\uc774 \ud655\ubcf4\ub3fc\uc57c \uc2e4\uc81c \uad6d\uc18c \ub3c4\ud3ec \uc81c\ud615\uc73c\ub85c \ud65c\uc6a9\ub420 \uc218 \uc788\ub2e4. CICA-EV \ud568\uc720 \uc81c\ud615\uc774 \ub2e8\uae30 \ucca9\ud3ec \uc2dc\ud5d8\uacfc 2\uc8fc \ubc18\ubcf5 \uc0ac\uc6a9 \uc870\uac74\uc5d0\uc11c \ud53c\ubd80 \uc790\uadf9\uc131\uc744 \ubcf4\uc774\uc9c0 \uc54a\uc558\ub2e4\ub294 \uc810\uc740 \ud53c\ubd80 \uac1c\uc120 \uc18c\uc7ac\ub85c\uc11c\uc758 \uc801\uc6a9 \uac00\ub2a5\uc131\uc744 \ub4b7\ubc1b\uce68\ud55c\ub2e4.<\/p>\n\n\n\n

\n\n\n\n

5. \ubaa8\uacf5 \uc9c0\ud45c \ubd84\uc11d<\/h2>\n\n\n\n

\ubaa8\uacf5 \uc9c0\ud45c\ub294 \ud53c\ubd80 \uc678\uad00 \uac1c\uc120\uacfc \uc9c1\uacb0\ub418\ub294 \ud575\uc2ec \ud3c9\uac00 \ud56d\ubaa9\uc774\ub2e4. \ub17c\ubb38\uc740 Antera 3D \uc7a5\ube44\ub97c \uc774\uc6a9\ud574 \ud3c9\uade0 \ubaa8\uacf5 \uba74\uc801, \ubaa8\uacf5 \ubc00\ub3c4, \ud3c9\uade0 \ubaa8\uacf5 \ubd80\ud53c, \ucd1d \ubaa8\uacf5 \ubd80\ud53c, \ucd5c\ub300 \ubaa8\uacf5 \uae4a\uc774 \ub4f1 \ub2e4\uc12f \uac00\uc9c0 \ubaa8\uacf5 \ud2b9\uc131\uc744 \uce21\uc815\ud588\ub2e4.<\/p>\n\n\n\n

\ucd08\ub85d\uc5d0\uc11c \uc81c\uc2dc\ub41c \uc8fc\uc694 \uacb0\uacfc\uc5d0 \ub530\ub974\uba74 \ud3c9\uade0 \ubaa8\uacf5 \uba74\uc801\uc740 17.9% \uac10\uc18c\ud588\uace0, \ubaa8\uacf5 \ubc00\ub3c4\ub294 26.9% \uac10\uc18c\ud588\ub2e4. \ud53c\ubd80 \ud45c\uba74 \uac70\uce60\uae30\ub294 9.0% \uac10\uc18c\ud588\ub2e4.<\/p>\n\n\n\n

\uc774 \uacb0\uacfc\ub294 CICA-EV \ud568\uc720 \uc81c\ud615\uc774 \ubaa8\uacf5 \uc678\uad00 \ubc0f \ud53c\ubd80 \ud45c\uba74 \uade0\uc77c\ub3c4\uc640 \uad00\ub828\ub41c \uc9c0\ud45c\uc5d0 \uc601\ud5a5\uc744 \uc904 \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud55c\ub2e4. \ubaa8\uacf5 \uba74\uc801 \uac10\uc18c\ub294 \uac1c\ubcc4 \ubaa8\uacf5\uc774 \uc2dc\uac01\uc801\uc73c\ub85c \ucc28\uc9c0\ud558\ub294 \uba74\uc801\uc758 \uac10\uc18c\ub97c \uc758\ubbf8\ud558\uba70, \ubaa8\uacf5 \ubc00\ub3c4 \uac10\uc18c\ub294 \ub2e8\uc704 \uba74\uc801\ub2f9 \uac80\ucd9c\ub418\ub294 \ubaa8\uacf5 \uc218 \ub610\ub294 \ubaa8\uacf5 \uac00\uc2dc\uc131 \ubcc0\ud654\uc640 \uad00\ub828\ub420 \uc218 \uc788\ub2e4. \ud53c\ubd80 \ud45c\uba74 \uac70\uce60\uae30 \uac10\uc18c\ub294 \ud53c\ubd80\uacb0 \uac1c\uc120 \uc9c0\ud45c\ub85c \ud574\uc11d\ub41c\ub2e4.<\/p>\n\n\n\n

\ub2e4\ub9cc \ubaa8\uacf5 \uc9c0\ud45c\ub294 \ud53c\uc9c0 \ubd84\ube44\ub7c9, \uac01\uc9c8 \uc0c1\ud0dc, \uc218\ubd84 \uc0c1\ud0dc, \ud53c\ubd80 \ud0c4\ub825, \uce21\uc815 \uc870\uba85 \ubc0f \uae30\uae30 \ubd84\uc11d \uc870\uac74\uc758 \uc601\ud5a5\uc744 \ubc1b\uc744 \uc218 \uc788\ub2e4. \ub530\ub77c\uc11c \ubcf8 \uacb0\uacfc\ub294 \ubaa8\uacf5 \uad6c\uc870\uac00 \uc601\uad6c\uc801\uc73c\ub85c \ucd95\uc18c\ub410\ub2e4\ub294 \uc758\ubbf8\uac00 \uc544\ub2c8\ub77c, 2\uc8fc \uad6d\uc18c \ub3c4\ud3ec \ud6c4 \ubaa8\uacf5 \uc678\uad00 \ubc0f \ud45c\uba74 \uc9c0\ud45c\uac00 \ud1b5\uacc4\uc801\uc73c\ub85c \uac1c\uc120\ub410\ub2e4\ub294 \uc758\ubbf8\ub85c \ud574\uc11d\ud558\ub294 \uac83\uc774 \uc801\uc808\ud558\ub2e4.<\/p>\n\n\n\n

\n\n\n\n

6. \uc8fc\ub984 \uc9c0\ud45c \ubd84\uc11d<\/h2>\n\n\n\n

\uc8fc\ub984 \uae4a\uc774\ub294 \ud53c\ubd80 \ub178\ud654 \ud3c9\uac00\uc5d0\uc11c \uac00\uc7a5 \uc9c1\uad00\uc801\uc778 \uc678\uad00 \uc9c0\ud45c\ub2e4. \ub17c\ubb38\uc740 \uc774\ub9c8, \ubbf8\uac04, \ub208\uac00, \ud314\uc790\uc8fc\ub984, \ubaa9 \ubd80\uc704 \ub4f1 \ub2e4\uc12f \ubd80\uc704\uc758 \uc8fc\ub984 \uae4a\uc774\ub97c \uce21\uc815\ud588\ub2e4. \uce21\uc815\uc740 Antera 3D\ub97c \uc774\uc6a9\ud574 \uae30\uc800 \uc2dc\uc810\uacfc 2\uc8fc \uc801\uc6a9 \ud6c4 \ube44\uad50\ud558\ub294 \ubc29\uc2dd\uc73c\ub85c \uc9c4\ud589\ub410\ub2e4.<\/p>\n\n\n\n

\ub17c\ubb38 \ucd08\ub85d\uc5d0 \ub530\ub974\uba74 \uc8fc\ub984 \uae4a\uc774\ub294 \ubd80\uc704\ubcc4\ub85c 7.8~18.8% \uac10\uc18c\ud588\ub2e4.<\/p>\n\n\n\n

\uc774 \uacb0\uacfc\ub294 CICA-EV \ud568\uc720 \uc81c\ud615\uc774 \ub2e8\uae30 \uc801\uc6a9 \uc870\uac74\uc5d0\uc11c \uc8fc\ub984 \uc678\uad00 \uac1c\uc120 \uc9c0\ud45c\ub97c \ubcf4\uc600\ub2e4\ub294 \uc758\ubbf8\ub97c \uac16\ub294\ub2e4. \ud2b9\ud788 \uc774\ub9c8, \ubbf8\uac04, \ub208\uac00, \ud314\uc790, \ubaa9\uc740 \ud45c\uc815 \uc8fc\ub984\uacfc \ud0c4\ub825 \uc800\ud558\uac00 \ud568\uaed8 \ub098\ud0c0\ub098\ub294 \ubd80\uc704\ub2e4. \uc774\ub4e4 \ubd80\uc704\uc5d0\uc11c \uc8fc\ub984 \uae4a\uc774 \uac10\uc18c\uac00 \uad00\ucc30\ub410\ub2e4\ub294 \uc810\uc740 CICA-EV \ud568\uc720 \uc81c\ud615\uc758 \ud53c\ubd80 \ud0c4\ub825 \ubc0f \ud45c\uba74 \uac1c\uc120 \uac00\ub2a5\uc131\uc744 \uc124\uba85\ud558\ub294 \uadfc\uac70\ub85c \ubcfc \uc218 \uc788\ub2e4.<\/p>\n\n\n\n

\uc8fc\ub984 \uc9c0\ud45c\ub294 \ud6c4\uc220\ud560 \ucf5c\ub77c\uac90 \ub300\uc0ac \uad00\ub828 \uc9c0\ud45c\uc640 \uc5f0\uacb0\ud574 \ud574\uc11d\ud560 \uc218 \uc788\ub2e4. \ud53c\ubd80 \ub178\ud654\ub294 \ucf5c\ub77c\uac90 \ud569\uc131 \uc800\ud558\uc640 \ubd84\ud574 \uc99d\uac00\uac00 \ud568\uaed8 \uc791\uc6a9\ud558\ub294 \uacfc\uc815\uc774\ub2e4. CICA-EV\uac00 COL1A1 \ubc1c\ud604 \ubc0f \ucf5c\ub77c\uac90 \uc0dd\uc131\ub7c9 \uc99d\uac00, MMP-1 \uc5b5\uc81c \uc9c0\ud45c\ub97c \ud568\uaed8 \uc81c\uc2dc\ud588\ub2e4\ub294 \uc810\uc740 \uc8fc\ub984 \uc678\uad00 \uac1c\uc120 \uacb0\uacfc\ub97c \uae30\uc804\uc801\uc73c\ub85c \uc124\uba85\ud560 \uc218 \uc788\ub294 \uadfc\uac70\ub97c \uc81c\uacf5\ud55c\ub2e4.<\/p>\n\n\n\n

\n\n\n\n

7. \ud53c\ubd80 \uc218\ubd84 \ubc0f \ud53c\ubd80 \ubc00\ub3c4 \uc9c0\ud45c \ubd84\uc11d<\/h2>\n\n\n\n

\ud53c\ubd80 \uc218\ubd84\uacfc \ud53c\ubd80 \ubc00\ub3c4\ub294 \ud53c\ubd80 \uc678\uad00\uacfc \uad6c\uc870\uc801 \uc548\uc815\uc131\uc744 \uc124\uba85\ud558\ub294 \uae30\ucd08 \uc9c0\ud45c\ub2e4. \ub17c\ubb38\uc740 MoistureMeter D\ub97c \uc774\uc6a9\ud574 0.5mm, 1.5mm, 2.5mm \uae4a\uc774\uc758 \ud53c\ubd80 \uc218\ubd84\uc744 \uce21\uc815\ud588\uace0, Ultrascan UC22 \uc7a5\ube44\ub97c \ud1b5\ud574 \ud53c\ubd80 \ubc00\ub3c4\ub97c \ud3c9\uac00\ud588\ub2e4.<\/p>\n\n\n\n

\uc8fc\uc694 \uacb0\uacfc\uc5d0 \ub530\ub974\uba74 0.5mm \uae4a\uc774\uc5d0\uc11c \ud53c\ubd80 \uc218\ubd84\uc740 7.9% \uc99d\uac00\ud588\uace0, \ud53c\ubd80 \ubc00\ub3c4\ub294 12.7% \uac1c\uc120\ub410\ub2e4.<\/p>\n\n\n\n

\ud53c\ubd80 \uc218\ubd84 \uc99d\uac00\ub294 \ud53c\ubd80 \ud45c\uba74 \uac70\uce60\uae30\uc640 \ubaa8\uacf5 \uc678\uad00 \uac1c\uc120\uc744 \uc124\uba85\ud558\ub294 \ubcf4\uc870 \uc9c0\ud45c\ub85c \ud574\uc11d\ub420 \uc218 \uc788\ub2e4. \ud53c\ubd80\uac00 \uac74\uc870\ud558\uba74 \uac01\uc9c8\uce35\uc774 \ubd88\uade0\uc77c\ud574\uc9c0\uace0 \ud45c\uba74 \uac70\uce60\uae30\uac00 \uc99d\uac00\ud574 \ubaa8\uacf5\uacfc \uc794\uc8fc\ub984\uc774 \ub354 \ub3c4\ub4dc\ub77c\uc838 \ubcf4\uc77c \uc218 \uc788\ub2e4. \ub530\ub77c\uc11c \uc218\ubd84 \uc99d\uac00\ub294 \ub2e8\uc21c \ubcf4\uc2b5 \ud6a8\uacfc\ub97c \ub118\uc5b4 \ud53c\ubd80\uacb0\uacfc \ubaa8\uacf5 \uc678\uad00 \uac1c\uc120\uc5d0 \uae30\uc5ec\ud560 \uc218 \uc788\ub2e4.<\/p>\n\n\n\n

\ud53c\ubd80 \ubc00\ub3c4 \uac1c\uc120\uc740 \ub354 \uc911\uc694\ud55c \uc758\ubbf8\ub97c \uac16\ub294\ub2e4. \ud53c\ubd80 \ubc00\ub3c4\ub294 \uc9c4\ud53c \uad6c\uc870\uac10, \uc870\uc9c1 \uce58\ubc00\ub3c4, \ud0c4\ub825\uc131\uacfc \uad00\ub828\ub41c \uc9c0\ud45c\ub85c \ud65c\uc6a9\ub420 \uc218 \uc788\ub2e4. CICA-EV \ud568\uc720 \uc81c\ud615\uc5d0\uc11c \ud53c\ubd80 \ubc00\ub3c4\uac00 12.7% \uac1c\uc120\ub410\ub2e4\ub294 \uacb0\uacfc\ub294 \ucf5c\ub77c\uac90 \ub300\uc0ac \uc9c0\ud45c\uc640 \ud568\uaed8 \ud574\uc11d\ud560 \ub54c \ud53c\ubd80 \uad6c\uc870 \uac1c\uc120 \uac00\ub2a5\uc131\uc744 \ub4b7\ubc1b\uce68\ud55c\ub2e4.<\/p>\n\n\n\n

\n\n\n\n

8. \ucf5c\ub77c\uac90 \ub300\uc0ac \uad00\ub828 \uae30\uc804 \ud3c9\uac00<\/h2>\n\n\n\n

CICA-EV\uc758 \ud53c\ubd80 \uac1c\uc120 \ubb3c\uc9c8\ub85c\uc11c \uac00\uc7a5 \uc911\uc694\ud55c \uadfc\uac70\ub294 \ucf5c\ub77c\uac90 \ub300\uc0ac\uc640 \uad00\ub828\ub41c \uc9c0\ud45c\ub2e4. \ud53c\ubd80 \ud0c4\ub825\uacfc \uc8fc\ub984 \ud615\uc131\uc740 \uc9c4\ud53c \ub0b4 \uc138\ud3ec\uc678\uae30\uc9c8, \ud2b9\ud788 \ucf5c\ub77c\uac90\uc758 \ud569\uc131\uacfc \ubd84\ud574 \uade0\ud615\uc5d0 \uc601\ud5a5\uc744 \ubc1b\ub294\ub2e4.<\/p>\n\n\n\n

\ub17c\ubb38\uc740 CICA-EV \uc801\uc6a9\uacfc \uad00\ub828\ud574 COL1A1 \ubc1c\ud604 \uc720\ub3c4 \ubc0f \ucf5c\ub77c\uac90 \uc0dd\uc131\ub7c9 \uc99d\uac00, MMP-1 \ud65c\uc131 \uc5b5\uc81c\ub97c \uc81c\uc2dc\ud588\ub2e4. \uc0ac\uc6a9\uc790\uac00 \uc81c\uacf5\ud55c \uad00\ub828 \ubcf4\ub3c4\uc790\ub8cc\uc640 \ub17c\ubb38 \uae30\ubc18 \uc218\uce58\uc5d0 \ub530\ub974\uba74 \ucf5c\ub77c\uac90 \uc0dd\uc131\ub7c9\uc740 \uc57d 2.37\ubc30 \uc99d\uac00\ud588\uace0, MMP-1 \ud65c\uc131\uc740 49.3% \uc5b5\uc81c\ub41c \uac83\uc73c\ub85c \ubcf4\uace0\ub410\ub2e4.<\/p>\n\n\n\n

COL1A1\uc740 \uc81c1\ud615 \ucf5c\ub77c\uac90 \ud569\uc131\uacfc \uad00\ub828\ub41c \ud575\uc2ec \uc720\uc804\uc790\ub2e4. \uc81c1\ud615 \ucf5c\ub77c\uac90\uc740 \uc9c4\ud53c\uc758 \uc8fc\uc694 \uad6c\uc870 \ub2e8\ubc31\uc9c8\ub85c, \ud53c\ubd80\uc758 \ud0c4\ub825\uacfc \ubc00\ub3c4 \uc720\uc9c0\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c\ub2e4. CICA-EV\uac00 COL1A1 \ubc1c\ud604\uc744 \uc720\ub3c4\ud558\uace0 \ucf5c\ub77c\uac90 \uc0dd\uc131\ub7c9 \uc99d\uac00\uc640 \uc5f0\uacb0\ub410\ub2e4\ub294 \uc810\uc740 CICA-EV\ub97c \ud0c4\ub825\u00b7\uc8fc\ub984 \uad00\ub828 \ud53c\ubd80 \uac1c\uc120 \ubb3c\uc9c8\ub85c \ud3c9\uac00\ud558\ub294 \ud575\uc2ec \uadfc\uac70\ub2e4.<\/p>\n\n\n\n

MMP-1\uc740 \ucf5c\ub77c\uac90 \ubd84\ud574\uc640 \uad00\ub828\ub41c \ud6a8\uc18c\ub2e4. \ud53c\ubd80 \ub178\ud654 \uacfc\uc815\uc5d0\uc11c\ub294 \ucf5c\ub77c\uac90 \ud569\uc131\uc774 \uc904\uc5b4\ub4dc\ub294 \ub3d9\uc2dc\uc5d0 \ubd84\ud574 \ud6a8\uc18c \ud65c\uc131\uc774 \uc99d\uac00\ud560 \uc218 \uc788\ub2e4. \ub530\ub77c\uc11c MMP-1 \uc5b5\uc81c\ub294 \ucf5c\ub77c\uac90 \ubcf4\uc874 \uac00\ub2a5\uc131\uacfc \uc5f0\uacb0\ub41c\ub2e4. CICA-EV\uac00 \ucf5c\ub77c\uac90 \uc0dd\uc131 \uc99d\uac00\uc640 MMP-1 \uc5b5\uc81c\ub97c \ub3d9\uc2dc\uc5d0 \ubcf4\uc600\ub2e4\ub294 \uc810\uc740 \ub2e8\uc77c \ubc29\ud5a5\uc758 \uc791\uc6a9\ubcf4\ub2e4 \ub354 \uac15\ud55c \ud574\uc11d\ub825\uc744 \uac16\ub294\ub2e4.<\/p>\n\n\n\n

KM\ub9ac\uc11c\uce58\ub294 \uc774 \uacb0\uacfc\ub97c CICA-EV\uc758 \uc911\uc2ec \uae30\uc804\uc73c\ub85c \ud3c9\uac00\ud55c\ub2e4. CICA-EV\ub294 \ub2e8\uc21c \uc218\ubd84 \uacf5\uae09 \uc18c\uc7ac\uac00 \uc544\ub2c8\ub77c, \ucf5c\ub77c\uac90 \ub300\uc0ac \uc870\uc808 \uac00\ub2a5\uc131\uc744 \ud1b5\ud574 \ud53c\ubd80 \ubc00\ub3c4, \ud0c4\ub825, \uc8fc\ub984 \uc678\uad00 \uac1c\uc120\uc744 \uc124\uba85\ud560 \uc218 \uc788\ub294 \ud6c4\ubcf4 \ubb3c\uc9c8\uc774\ub2e4.<\/p>\n\n\n\n

\n\n\n\n

9. CICA-EV\uc758 \ud53c\ubd80 \uac1c\uc120 \uc791\uc6a9 \ubaa8\ub378<\/h2>\n\n\n\n

\ubcf8 \ub9ac\ud3ec\ud2b8\ub294 CICA-EV\uc758 \ud53c\ubd80 \uac1c\uc120 \uac00\ub2a5\uc131\uc744 \uc138 \uac00\uc9c0 \ucd95\uc73c\ub85c \uc815\ub9ac\ud55c\ub2e4.<\/p>\n\n\n\n

9.1 \ucf5c\ub77c\uac90 \ub300\uc0ac \uc870\uc808 \ucd95<\/h2>\n\n\n\n

\uccab \ubc88\uc9f8 \ucd95\uc740 \ucf5c\ub77c\uac90 \ub300\uc0ac \uc870\uc808\uc774\ub2e4. CICA-EV\ub294 COL1A1 \ubc1c\ud604 \uc720\ub3c4\uc640 \ucf5c\ub77c\uac90 \uc0dd\uc131\ub7c9 \uc99d\uac00 \uc9c0\ud45c\ub97c \ud1b5\ud574 \uc9c4\ud53c \uad6c\uc870 \uc720\uc9c0 \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud588\ub2e4. \ub3d9\uc2dc\uc5d0 MMP-1 \uc5b5\uc81c \uc9c0\ud45c\ub97c \ud1b5\ud574 \ucf5c\ub77c\uac90 \ubd84\ud574 \uc5b5\uc81c \uac00\ub2a5\uc131\ub3c4 \ubcf4\uc600\ub2e4.<\/p>\n\n\n\n

\uc774 \ucd95\uc740 \ud53c\ubd80 \ud0c4\ub825, \uc8fc\ub984 \uae4a\uc774, \ud53c\ubd80 \ubc00\ub3c4 \uc9c0\ud45c\uc640 \uc5f0\uacb0\ub41c\ub2e4. \ucf5c\ub77c\uac90 \uc0dd\uc131\uc774 \uc99d\uac00\ud558\uace0 \ubd84\ud574\uac00 \uc5b5\uc81c\ub418\ub294 \ubc29\ud5a5\uc740 \ud53c\ubd80 \uad6c\uc870\uc758 \uc548\uc815\uc131\uacfc \uc678\uad00 \uac1c\uc120\uc744 \uc124\uba85\ud558\ub294 \ud575\uc2ec \uacbd\ub85c\ub2e4.<\/p>\n\n\n\n

9.2 \ud53c\ubd80 \ud45c\uba74 \uade0\uc77c\ub3c4 \uac1c\uc120 \ucd95<\/h2>\n\n\n\n

\ub450 \ubc88\uc9f8 \ucd95\uc740 \ud53c\ubd80 \ud45c\uba74 \uade0\uc77c\ub3c4 \uac1c\uc120\uc774\ub2e4. \ud3c9\uade0 \ubaa8\uacf5 \uba74\uc801, \ubaa8\uacf5 \ubc00\ub3c4, \ud53c\ubd80 \ud45c\uba74 \uac70\uce60\uae30, \uc8fc\ub984 \uae4a\uc774 \uc9c0\ud45c\ub294 \ubaa8\ub450 \ud53c\ubd80 \ud45c\uba74\uc758 \uc2dc\uac01\uc801 \uade0\uc77c\ub3c4\uc640 \uad00\ub828\ub41c\ub2e4. CICA-EV \ud568\uc720 \uc81c\ud615 \uc801\uc6a9 \ud6c4 \uc774\ub4e4 \uc9c0\ud45c\uac00 \uac1c\uc120\ub410\ub2e4\ub294 \uc810\uc740 \ud53c\ubd80 \uc678\uad00 \uac1c\uc120 \uac00\ub2a5\uc131\uc744 \ubcf4\uc5ec\uc900\ub2e4.<\/p>\n\n\n\n

\uc774 \ucd95\uc5d0\uc11c CICA-EV\ub294 \ubaa8\uacf5\uacfc \uc8fc\ub984\uc744 \ubcc4\uac1c\ub85c \ub2e4\ub8e8\ub294 \ubb3c\uc9c8\uc774 \uc544\ub2c8\ub77c, \ud53c\ubd80 \ud45c\uba74\uc758 \ubcf5\ud569\uc801 \ubd88\uade0\uc77c\uc131\uc744 \uc644\ud654\ud558\ub294 \ud6c4\ubcf4 \ubb3c\uc9c8\ub85c \ud574\uc11d\ub41c\ub2e4.<\/p>\n\n\n\n

9.3 \uc218\ubd84\u00b7\ubc00\ub3c4 \ubcf4\uac15 \ucd95<\/h2>\n\n\n\n

\uc138 \ubc88\uc9f8 \ucd95\uc740 \uc218\ubd84\uacfc \ud53c\ubd80 \ubc00\ub3c4 \ubcf4\uac15\uc774\ub2e4. \ud53c\ubd80 \uc218\ubd84 \uc99d\uac00\ub294 \uac01\uc9c8\uce35 \ubc0f \ud45c\ud53c \uc0c1\ud0dc\uc640 \uad00\ub828\ub418\uace0, \ud53c\ubd80 \ubc00\ub3c4 \uc99d\uac00\ub294 \uc9c4\ud53c \uad6c\uc870\uac10\uacfc \uc5f0\uacb0\ub41c\ub2e4. CICA-EV \ud568\uc720 \uc81c\ud615\uc774 \uc218\ubd84\uacfc \ubc00\ub3c4 \uc9c0\ud45c\uc5d0\uc11c \uac1c\uc120\uc744 \ubcf4\uc778 \uc810\uc740 \ud53c\ubd80 \ud45c\uba74\uacfc \uc9c4\ud53c \uc591\ucabd\uc5d0 \uac78\uce5c \uac1c\uc120 \uac00\ub2a5\uc131\uc744 \uc2dc\uc0ac\ud55c\ub2e4.<\/p>\n\n\n\n

\uc774 \uc138 \ucd95\uc744 \uc885\ud569\ud558\uba74 CICA-EV\ub294 \u201c\uc9c4\uc815\ud615 \uc2dc\uce74 \uc18c\uc7ac\u201d\uac00 \uc544\ub2c8\ub77c \u201c\ucf5c\ub77c\uac90 \ub300\uc0ac\u00b7\ud45c\uba74 \uade0\uc77c\ub3c4\u00b7\uc218\ubd84 \ubc00\ub3c4 \uac1c\uc120\uc744 \ud568\uaed8 \uc124\uba85\ud560 \uc218 \uc788\ub294 \ubcf5\ud569 \ud53c\ubd80 \uac1c\uc120 \ubb3c\uc9c8\u201d\ub85c \ubd84\ub958\ud560 \uc218 \uc788\ub2e4.<\/p>\n\n\n\n

\n\n\n\n

10. \uae30\uc874 \ubcd1\ud480\u00b7\uc2dc\uce74 \uc18c\uc7ac\uc640\uc758 \uad6c\ubd84<\/h2>\n\n\n\n

\uae30\uc874 \ubcd1\ud480\u00b7\uc2dc\uce74 \uc18c\uc7ac\ub294 \uc8fc\ub85c \ud53c\ubd80 \uc9c4\uc815, \uc7a5\ubcbd \uad00\ub9ac, \ubbfc\uac10\uc131 \ud53c\ubd80 \ubcf4\uc870 \uc131\ubd84\uc73c\ub85c \uc778\uc2dd\ub3fc \uc654\ub2e4. \uc774\ub7ec\ud55c \uc778\uc2dd\uc740 \ubcd1\ud480\uc758 \ud56d\uc5fc, \ud56d\uc0b0\ud654, \uc0c1\ucc98 \ud68c\ubcf5 \uad00\ub828 \uc5f0\uad6c\uc640 \ud654\uc7a5\ud488 \uc2dc\uc7a5 \ub0b4 \ud65c\uc6a9 \uacbd\ud5d8\uc5d0 \uae30\ubc18\ud55c\ub2e4.<\/p>\n\n\n\n

CICA-EV\ub294 \uc774 \ubc94\uc8fc\ub97c \ud655\uc7a5\ud55c\ub2e4. \ub17c\ubb38\uc740 CICA \uc720\ub798 EV\uac00 \ud3ec\ud568\ub41c \uad6d\uc18c \ub3c4\ud3ec \uc81c\ud615\uc5d0\uc11c \ubaa8\uacf5, \uc8fc\ub984, \uc218\ubd84, \ud53c\ubd80 \ubc00\ub3c4, \uc790\uadf9\uc131 \uc9c0\ud45c\uac00 \ud568\uaed8 \ud3c9\uac00\ub410\uc74c\uc744 \ubcf4\uc5ec\uc900\ub2e4. \ub610\ud55c CICA \uc720\ub798 EV\uac00 \uc77c\ubc18 \ucd94\ucd9c\ubb3c\ubcf4\ub2e4 \ud53c\ubd80 \uc7ac\uc0dd \ubc0f \uc5fc\uc99d \uc644\ud654 \uce21\uba74\uc5d0\uc11c \uac15\ud654\ub41c \ud6a8\ub2a5\uc744 \ubcf4\uc778 \uc5f0\uad6c \ud750\ub984\uc744 \ubc30\uacbd\uc73c\ub85c \uc81c\uc2dc\ud55c\ub2e4.<\/p>\n\n\n\n

\ub530\ub77c\uc11c CICA-EV\ub294 \uc77c\ubc18 \ubcd1\ud480 \ucd94\ucd9c\ubb3c\uc758 \uace0\ub18d\ucd95 \ubc84\uc804\uc774 \uc544\ub2c8\ub2e4. \ubcd1\ud480 \uc720\ub798 \ubb3c\uc9c8\uc744 \uc138\ud3ec\uc678\uc18c\ud3ec \ud615\ud0dc\ub85c \ubd84\ub9ac\u00b7\uc815\uc81c\ud558\uace0, \ub098\ub178 \uc18c\ud3ec\uccb4 \uae30\ubc18\uc73c\ub85c \ud53c\ubd80 \uac1c\uc120 \uc9c0\ud45c\ub97c \ud3c9\uac00\ud55c \uc18c\uc7ac\ub2e4. \uc774 \ucc28\uc774\ub294 CICA-EV\uc758 \ud559\uc220\uc801 \uc704\uce58\ub97c \uacb0\uc815\ud558\ub294 \ud575\uc2ec \uc694\uc18c\ub2e4.<\/p>\n\n\n\n

\n\n\n\n

11. \ud575\uc2ec \uc9c0\ud45c \uc694\uc57d<\/h2>\n\n\n\n
\ud3c9\uac00 \uc601\uc5ed<\/th>\uad00\ucc30 \uc9c0\ud45c<\/th>\uacb0\uacfc<\/th>\ud53c\ubd80 \uac1c\uc120 \ubb3c\uc9c8 \uad00\uc810\uc758 \uc758\ubbf8<\/th><\/tr><\/thead>
\ud53c\ubd80 \uc790\uadf9\uc131<\/td>24\uc2dc\uac04 \ud328\uce58 \ud14c\uc2a4\ud2b8<\/td>\uc790\uadf9 \uc9c0\uc218 0.00<\/td>\uad6d\uc18c \ub3c4\ud3ec \uc81c\ud615\uc758 \ud53c\ubd80 \uc801\ud569\uc131 \uadfc\uac70<\/td><\/tr>
\ubaa8\uacf5 \uc678\uad00<\/td>\ud3c9\uade0 \ubaa8\uacf5 \uba74\uc801<\/td>17.9% \uac10\uc18c<\/td>\ubaa8\uacf5 \uc678\uad00 \uac1c\uc120 \uac00\ub2a5\uc131<\/td><\/tr>
\ubaa8\uacf5 \uc678\uad00<\/td>\ubaa8\uacf5 \ubc00\ub3c4<\/td>26.9% \uac10\uc18c<\/td>\ud53c\ubd80 \ud45c\uba74 \uade0\uc77c\ub3c4 \uac1c\uc120 \uac00\ub2a5\uc131<\/td><\/tr>
\ud53c\ubd80\uacb0<\/td>\ud53c\ubd80 \ud45c\uba74 \uac70\uce60\uae30<\/td>9.0% \uac10\uc18c<\/td>\ud45c\uba74 \uacb0 \uac1c\uc120 \uc9c0\ud45c<\/td><\/tr>
\uc8fc\ub984 \uc678\uad00<\/td>\uc8fc\ub984 \uae4a\uc774<\/td>7.8~18.8% \uac10\uc18c<\/td>\ubd80\uc704\ubcc4 \uc8fc\ub984 \uc678\uad00 \uac1c\uc120 \uac00\ub2a5\uc131<\/td><\/tr>
\ud53c\ubd80 \uc218\ubd84<\/td>0.5mm \uae4a\uc774 \uc218\ubd84<\/td>7.9% \uc99d\uac00<\/td>\ud53c\ubd80 \uc218\ubd84 \ubcf4\uac15 \uac00\ub2a5\uc131<\/td><\/tr>
\ud53c\ubd80 \uad6c\uc870<\/td>\ud53c\ubd80 \ubc00\ub3c4<\/td>12.7% \uac1c\uc120<\/td>\uc9c4\ud53c \uad6c\uc870\uac10 \ubc0f \uce58\ubc00\ub3c4 \uac1c\uc120 \uc9c0\ud45c<\/td><\/tr>
\ucf5c\ub77c\uac90 \ud569\uc131<\/td>COL1A1\u00b7\ucf5c\ub77c\uac90 \uc0dd\uc131<\/td>\uc57d 2.37\ubc30 \uc99d\uac00<\/td>\ucf5c\ub77c\uac90 \uc0dd\uc131 \uad00\ub828 \uae30\uc804 \uac00\ub2a5\uc131<\/td><\/tr>
\ucf5c\ub77c\uac90 \ubd84\ud574<\/td>MMP-1 \ud65c\uc131<\/td>49.3% \uc5b5\uc81c<\/td>\ucf5c\ub77c\uac90 \ubd84\ud574 \uc5b5\uc81c \uac00\ub2a5\uc131<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
\n\n\n\n

12. \uc5f0\uad6c \ud574\uc11d\uc758 \ud55c\uacc4<\/h2>\n\n\n\n

CICA-EV\ub294 \ud53c\ubd80 \uac1c\uc120 \ubb3c\uc9c8\ub85c\uc11c \uc720\uc758\ubbf8\ud55c \uc9c0\ud45c\ub97c \uc81c\uc2dc\ud588\uc9c0\ub9cc, \ud574\uc11d \ubc94\uc704\ub294 \uba85\ud655\ud574\uc57c \ud55c\ub2e4.<\/p>\n\n\n\n

\uccab\uc9f8, \uc778\uccb4 \uc801\uc6a9\uc2dc\ud5d8 \uae30\uac04\uc740 2\uc8fc\ub85c \uc81c\ud55c\ub41c\ub2e4.
\ub17c\ubb38\uc0c1 \ud6a8\ub2a5 \ud3c9\uac00\ub294 14\uc77c \uc5f0\uc18d \uc0ac\uc6a9 \ud6c4 \uce21\uc815\ub41c \uacb0\uacfc\ub2e4. \uc774\ub294 \ub2e8\uae30 \uc801\uc6a9 \ud6c4 \ud53c\ubd80 \uc9c0\ud45c \uac1c\uc120\uc744 \ubcf4\uc5ec\uc8fc\ub294 \uc790\ub8cc\ub2e4. \uc7a5\uae30 \uc0ac\uc6a9 \uc2dc \ud6a8\uacfc \uc9c0\uc18d\uc131, \ub204\uc801 \ud6a8\uacfc, \uc0ac\uc6a9 \uc911\ub2e8 \ud6c4 \ubcc0\ud654\ub294 \ucd94\uac00 \uc5f0\uad6c\uac00 \ud544\uc694\ud558\ub2e4.<\/p>\n\n\n\n

\ub458\uc9f8, \ud6a8\ub2a5 \ud3c9\uac00 \ub300\uc0c1\uc740 20\uba85\uc758 \uc131\uc778 \uc5ec\uc131\uc774\ub2e4.
\uc2dc\ud5d8\uad70\uc740 \ud3c9\uade0 \uc5f0\ub839 50.7\uc138\uc600\uace0, \ucd5c\uc885 \ubd84\uc11d \ub300\uc0c1\uc740 20\uba85\uc774\uc5c8\ub2e4. \ub2e4\uc591\ud55c \uc5f0\ub839, \uc131\ubcc4, \ud53c\ubd80 \uc720\ud615, \ubbfc\uac10\ub3c4, \uc778\uc885\uc801 \ubc30\uacbd\uc5d0\uc11c \ub3d9\uc77c\ud55c \uacb0\uacfc\uac00 \uc7ac\ud604\ub418\ub294\uc9c0\ub294 \ud6c4\uc18d \uc5f0\uad6c\uac00 \ud544\uc694\ud558\ub2e4.<\/p>\n\n\n\n

\uc14b\uc9f8, \uc778\uccb4 \uc801\uc6a9\uc2dc\ud5d8\uc740 CICA-EV \ub2e8\ub3c5 \uc6d0\ub8cc\uac00 \uc544\ub2c8\ub77c CICA-EV \ud568\uc720 \uc81c\ud615\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c\ub2e4.
\ub530\ub77c\uc11c \ubaa8\ub4e0 \ud53c\ubd80 \uac1c\uc120 \uc9c0\ud45c\ub97c CICA-EV \ub2e8\ub3c5 \ud6a8\uacfc\ub85c \ub2e8\uc815\ud558\uae30\ubcf4\ub2e4, CICA-EV\uac00 \ud3ec\ud568\ub41c \uad6d\uc18c \ub3c4\ud3ec \uc81c\ud615\uc758 \uacb0\uacfc\ub85c \ud574\uc11d\ud574\uc57c \ud55c\ub2e4. \ub2e4\ub9cc \ud574\ub2f9 \uc81c\ud615\uc758 \ud575\uc2ec \ud65c\uc131 \uc18c\uc7ac\uac00 CICA \uc720\ub798 EV\ub77c\ub294 \uc810\uc5d0\uc11c CICA-EV\uc758 \uc18c\uc7ac \uac00\ub2a5\uc131\uc744 \ud3c9\uac00\ud558\ub294 \uadfc\uac70\ub85c\ub294 \ucda9\ubd84\ud55c \uc758\ubbf8\uac00 \uc788\ub2e4.<\/p>\n\n\n\n

\ub137\uc9f8, \ubcf8 \ub9ac\ud3ec\ud2b8\ub294 \ud654\uc7a5\ud488 \uc18c\uc7ac \ubd84\uc11d \ubcf4\uace0\uc11c\ub2e4.
CICA-EV\ub97c \uc758\uc57d\ud488, \uce58\ub8cc\uc81c, \ud53c\ubd80 \uc9c8\ud658 \uac1c\uc120 \ubb3c\uc9c8\ub85c \uaddc\uc815\ud558\uc9c0 \uc54a\ub294\ub2e4. \ubcf8 \ub9ac\ud3ec\ud2b8\uc5d0\uc11c \ub9d0\ud558\ub294 \ud53c\ubd80 \uac1c\uc120\uc740 \ud654\uc7a5\ud488 \uc601\uc5ed\uc5d0\uc11c\uc758 \ubaa8\uacf5 \uc678\uad00, \uc8fc\ub984 \uae4a\uc774, \uc218\ubd84, \ud53c\ubd80 \ubc00\ub3c4, \ud53c\ubd80\uacb0, \uc790\uadf9\uc131 \uc9c0\ud45c \uac1c\uc120\uc744 \uc758\ubbf8\ud55c\ub2e4.<\/p>\n\n\n\n

\n\n\n\n

13. \uc885\ud569 \ud3c9\uac00<\/h2>\n\n\n\n

CICA-EV\ub294 \ubcd1\ud480 \uc720\ub798 \uc138\ud3ec\uc678\uc18c\ud3ec\ub97c \uae30\ubc18\uc73c\ub85c \ud55c \uace0\uae30\ub2a5\uc131 \ud53c\ubd80 \uac1c\uc120 \ud6c4\ubcf4 \ubb3c\uc9c8\uc774\ub2e4. \uae30\uc874 \uc2dc\uce74 \uc18c\uc7ac\uac00 \uc8fc\ub85c \uc9c4\uc815\uacfc \uc7a5\ubcbd \uad00\ub9ac \uc774\ubbf8\uc9c0\uc5d0 \uba38\ubb3c\ub800\ub2e4\uba74, CICA-EV\ub294 \ucf5c\ub77c\uac90 \ub300\uc0ac, \ubaa8\uacf5 \uc678\uad00, \uc8fc\ub984 \uae4a\uc774, \ud53c\ubd80 \uc218\ubd84, \ud53c\ubd80 \ubc00\ub3c4, \uc800\uc790\uadf9\uc131 \uc9c0\ud45c\ub97c \ud568\uaed8 \uc81c\uc2dc\ud55c\ub2e4\ub294 \uc810\uc5d0\uc11c \ud655\uc7a5\ub41c \uae30\ub2a5\uc131\uc744 \uac16\ub294\ub2e4.<\/p>\n\n\n\n

\ud2b9\ud788 \ucf5c\ub77c\uac90 \uc0dd\uc131\ub7c9 \uc57d 2.37\ubc30 \uc99d\uac00\uc640 MMP-1 \ud65c\uc131 49.3% \uc5b5\uc81c\ub294 CICA-EV\uc758 \ud575\uc2ec \uae30\uc804\uc73c\ub85c \ud3c9\uac00\ub41c\ub2e4. \uc774 \ub450 \uc9c0\ud45c\ub294 \ud53c\ubd80 \ub178\ud654\uc758 \uc911\uc2ec\ucd95\uc778 \ucf5c\ub77c\uac90 \uc0dd\uc131 \uac10\uc18c\uc640 \ubd84\ud574 \uc99d\uac00 \ubb38\uc81c\ub97c \ub3d9\uc2dc\uc5d0 \uc124\uba85\ud55c\ub2e4. \uc5ec\uae30\uc5d0 \ubaa8\uacf5 \uba74\uc801 17.9% \uac10\uc18c, \ubaa8\uacf5 \ubc00\ub3c4 26.9% \uac10\uc18c, \ud53c\ubd80 \uac70\uce60\uae30 9.0% \uac10\uc18c, \uc8fc\ub984 \uae4a\uc774 7.8~18.8% \uac10\uc18c, \ud53c\ubd80 \uc218\ubd84 7.9% \uc99d\uac00, \ud53c\ubd80 \ubc00\ub3c4 12.7% \uac1c\uc120 \uacb0\uacfc\uac00 \uacb0\ud569\ub418\uba74\uc11c CICA-EV\ub294 \ub2e8\uc77c \uae30\ub2a5\uc131 \uc6d0\ub8cc\ubcf4\ub2e4 \ub113\uc740 \ud53c\ubd80 \uac1c\uc120 \ubc94\uc704\ub97c \uac16\ub294\ub2e4.<\/p>\n\n\n\n

KM\ub9ac\uc11c\uce58\ub294 CICA-EV\ub97c \u201c\uc9c4\uc815\ud615 \uc2dc\uce74\u201d\uc5d0\uc11c \u201c\uac1c\uc120\ud615 \ubc14\uc774\uc624 \uc2dc\uce74\u201d\ub85c \uc9c4\ud654\ud55c \uc18c\uc7ac\ub85c \ud3c9\uac00\ud55c\ub2e4. \uc774 \ud45c\ud604\uc740 \ub9c8\ucf00\ud305 \uc218\uc0ac\uac00 \uc544\ub2c8\ub77c \uc18c\uc7ac \ud574\uc11d\uc0c1\uc758 \ubd84\ub958\ub2e4. CICA-EV\ub294 \ubcd1\ud480 \uc720\ub798 \uc6d0\ub8cc\uc758 \uc548\uc804\ud558\uace0 \uce5c\uc219\ud55c \uc774\ubbf8\uc9c0\ub97c \uc720\uc9c0\ud558\uba74\uc11c\ub3c4, \uc138\ud3ec\uc678\uc18c\ud3ec \uae30\ubc18 \uae30\uc220\uacfc \uc815\ub7c9 \uc9c0\ud45c\ub97c \ud1b5\ud574 \ud53c\ubd80 \uad6c\uc870 \ubc0f \uc678\uad00 \uac1c\uc120 \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud55c \ubb3c\uc9c8\uc774\ub2e4.<\/p>\n\n\n\n

\n\n\n\n

14. \uacb0\ub860<\/h2>\n\n\n\n

\ubcf8 \ub9ac\ud3ec\ud2b8\ub294 CICA-EV\ub97c \ubcd1\ud480 \uc720\ub798 \uc138\ud3ec\uc678\uc18c\ud3ec \uae30\ubc18 \ud53c\ubd80 \uac1c\uc120 \ud6c4\ubcf4 \ubb3c\uc9c8\ub85c \ud3c9\uac00\ud55c\ub2e4. \uacf5\uac1c \ub17c\ubb38\uc5d0\uc11c \uc81c\uc2dc\ub41c \uc790\ub8cc\uc5d0 \ub530\ub974\uba74 CICA-EV \ud568\uc720 \uad6d\uc18c \ub3c4\ud3ec \uc81c\ud615\uc740 \ud53c\ubd80 \uc790\uadf9\uc131 \ud3c9\uac00\uc5d0\uc11c \uc790\uadf9 \uc9c0\uc218 0.00\uc744 \ubcf4\uc600\uace0, 2\uc8fc \uc801\uc6a9\uc2dc\ud5d8\uc5d0\uc11c \ubaa8\uacf5 \uc678\uad00, \uc8fc\ub984 \uae4a\uc774, \ud53c\ubd80 \uc218\ubd84, \ud53c\ubd80 \ubc00\ub3c4, \ud53c\ubd80 \ud45c\uba74 \uac70\uce60\uae30 \uad00\ub828 \uc9c0\ud45c \uac1c\uc120\uc744 \ub098\ud0c0\ub0c8\ub2e4.<\/p>\n\n\n\n

CICA-EV\uc758 \ud575\uc2ec \uac00\uce58\ub294 \ucf5c\ub77c\uac90 \ub300\uc0ac \uc870\uc808 \uac00\ub2a5\uc131\uc5d0 \uc788\ub2e4. COL1A1 \ubc1c\ud604 \uc720\ub3c4, \ucf5c\ub77c\uac90 \uc0dd\uc131\ub7c9 \uc99d\uac00, MMP-1 \uc5b5\uc81c \uc9c0\ud45c\ub294 CICA-EV\uac00 \ub2e8\uc21c \ubcf4\uc2b5\u00b7\uc9c4\uc815 \uc18c\uc7ac\ub97c \ub118\uc5b4 \ud53c\ubd80 \ud0c4\ub825\uacfc \uad6c\uc870 \uc720\uc9c0\uc5d0 \uad00\uc5ec\ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud55c\ub2e4. \uc774\ub7ec\ud55c \uae30\uc804 \uc9c0\ud45c\uc640 \uc778\uccb4 \uc801\uc6a9\uc2dc\ud5d8 \uacb0\uacfc\uac00 \ud568\uaed8 \uc81c\uc2dc\ub410\ub2e4\ub294 \uc810\uc740 CICA-EV\ub97c \ubcf5\ud569 \ud53c\ubd80 \uac1c\uc120 \ubb3c\uc9c8\ub85c \ud3c9\uac00\ud558\ub294 \uadfc\uac70\uac00 \ub41c\ub2e4.<\/p>\n\n\n\n

\ub2e4\ub9cc \ud604\uc7ac \uadfc\uac70\ub294 2\uc8fc \ub2e8\uae30 \uc801\uc6a9\uc2dc\ud5d8\uacfc \uc81c\ud55c\ub41c \ub300\uc0c1\uad70\uc744 \uae30\ubc18\uc73c\ub85c \ud55c\ub2e4. \ud5a5\ud6c4 CICA-EV\uc758 \ud559\uc220\uc801 \uc2e0\ub8b0\ub3c4\ub97c \uac15\ud654\ud558\uae30 \uc704\ud574\uc11c\ub294 \uc7a5\uae30 \uc801\uc6a9\uc2dc\ud5d8, \ub300\uaddc\ubaa8 \uc2dc\ud5d8, \ub2e4\uc591\ud55c \ud53c\ubd80 \uc720\ud615\ubcc4 \ubd84\uc11d, CICA-EV \ub18d\ub3c4\ubcc4 \ube44\uad50, \uc77c\ubc18 \ubcd1\ud480 \ucd94\ucd9c\ubb3c\uacfc\uc758 \uc9c1\uc811 \ube44\uad50 \uc5f0\uad6c\uac00 \ud544\uc694\ud558\ub2e4.<\/p>\n\n\n\n

\uadf8\ub7fc\uc5d0\ub3c4 \ud604\uc7ac\uae4c\uc9c0 \uacf5\uac1c\ub41c \uc790\ub8cc\ub97c \uae30\uc900\uc73c\ub85c \ubcfc \ub54c CICA-EV\ub294 \ud654\uc7a5\ud488 \uc18c\uc7ac \uc601\uc5ed\uc5d0\uc11c \ubaa8\uacf5 \uc678\uad00, \uc8fc\ub984 \uae4a\uc774, \ud53c\ubd80 \uc218\ubd84, \ud53c\ubd80 \ubc00\ub3c4, \ud53c\ubd80\uacb0, \uc800\uc790\uadf9\uc131\uc744 \ub3d9\uc2dc\uc5d0 \uc124\uba85\ud560 \uc218 \uc788\ub294 \uc720\ub9dd\ud55c \ud53c\ubd80 \uac1c\uc120 \ud6c4\ubcf4 \ubb3c\uc9c8\uc774\ub2e4. \ubcd1\ud480 \uc720\ub798 \uc6d0\ub8cc\uc758 \uce5c\uc219\uc131\uacfc \uc138\ud3ec\uc678\uc18c\ud3ec \uae30\ubc18 \uae30\uc220\uc758 \uace0\ub3c4\uc131\uc774 \uacb0\ud569\ub410\ub2e4\ub294 \uc810\uc5d0\uc11c CICA-EV\ub294 \ucc28\uc138\ub300 \ubc14\uc774\uc624 \uc2dc\uce74 \uc18c\uc7ac\ub85c \ubd84\ub958\ud560 \uc218 \uc788\ub2e4.<\/p>\n\n\n\n

\n\n\n\n

\ucc38\uace0\ubb38\ud5cc<\/h2>\n\n\n\n

Park, Hannah S., and Sehyun Shin. \u201cClinical Efficacy and Safety Evaluation of a Centella asiatica (CICA)-Derived Extracellular Vesicle Formulation for Anti-Aging Skincare.\u201d Cosmetics, 2025, 12(4), 135. DOI: 10.3390\/cosmetics12040135.<\/p>\n","protected":false},"excerpt":{"rendered":"

\ubcd1\ud480 \uc720\ub798 \uc138\ud3ec\uc678\uc18c\ud3ec CICA-EV\uc758 \ud53c\ubd80 \uac1c\uc120 \ubb3c\uc9c8 \uac00\ub2a5\uc131 \ubd84\uc11d \ucf5c\ub77c\uac90 \ub300\uc0ac, \ubaa8\uacf5 \uc9c0\ud45c, \uc8fc\ub984 \uae4a\uc774, \ud53c\ubd80 \uc218\ubd84 \ubc0f \ud53c\ubd80 \ubc00\ub3c4 \uac1c\uc120 \uac00\ub2a5\uc131\uc744 \uc911\uc2ec\uc73c\ub85c \ubc1c\ud589\uae30\uad00KM\ub9ac\uc11c\uce58 \ubd84\uc11d \ub300\uc0c1Centella asiatica-derived extracellular vesicles, CICA-EV \uc8fc\uc694 \ubd84\uc11d \ubb38\ud5ccHannah S. Park and Sehyun Shin, \u201cClinical Efficacy and Safety Evaluation of a Centella asiatica (CICA)-Derived Extracellular Vesicle Formulation for Anti-Aging Skincare,\u201d Cosmetics, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[33],"tags":[],"_links":{"self":[{"href":"https:\/\/komta.or.kr\/index.php?rest_route=\/wp\/v2\/posts\/446"}],"collection":[{"href":"https:\/\/komta.or.kr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/komta.or.kr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/komta.or.kr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/komta.or.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=446"}],"version-history":[{"count":1,"href":"https:\/\/komta.or.kr\/index.php?rest_route=\/wp\/v2\/posts\/446\/revisions"}],"predecessor-version":[{"id":447,"href":"https:\/\/komta.or.kr\/index.php?rest_route=\/wp\/v2\/posts\/446\/revisions\/447"}],"wp:attachment":[{"href":"https:\/\/komta.or.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=446"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/komta.or.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=446"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/komta.or.kr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=446"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}